ISSN: 1300-0365
Dil: Türkçe
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Deneysel Fototromboz Modelinde E Vitamininin Antioksidan Etkinliğinin İnce Yapı Düzeyinde İncelenmesi
Güngör SOBACI*, Osman ÖZCAN**, Erol YILDIRIM***, Ali İhsan İNCASU****, Hüseyin GÜN*****, Ayhan KUBAR******
*Doç.Dr. GATA Göz Hastalıkları ABD,**Yard.Doç. Dr. GATA Hisyoloji-Embriyoloji BD,***Prof. Dr. GATA Göz Hastalıkları ABD,****Uz. Dr. Ankara Hastanesi Göz Kliniği Uzmanı,*****Doç. Dr. GATA Mikrobiyoloji ABD,******Uz.Öğr. GATA Mikrobiyoloji ABD, ANKARA
AN ULTRASTRUCTURAL ANALYSIS OF ANTIOXIDANT EFFECT OF VITAMIN E ON AN EXPERIMENTAL
PHOTOTHROMBOSIS MODEL
In recent years, the novel technique, photochemically induced thrombosis (photothrombosis) has been one of the
field of interest in vision researches. In this study, the antioxidant effect of vitamin E in the photothrombosis of the
choroidal vasculature of IV rose bengal injected albino rats induced by the light of an operation microscope was
evaluated ultrastructuraly. No cellular pathology was present in the control group with no previous IV rose bengal
injection (n=10). While minimal histopathological changes were observed, In the vitamin E pretreated (600 mg/kg
subcutaneous injection for 5 days) rats (n-10) severe cellular damage limited to anteriolar endothelium was observed in
photothrombosis group without vitamin E pretreatment (n**10). Results of the present, study suggested that vitamin E
prevented the photochemical damage to endothelium by its antioxidant effects.Keywords: Photothrombosis, Vitamin E, infrastructure, Rat
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