ISSN: 1300-0365
Dil: Türkçe
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The Investigation Of Anti-cataractogenic Efficacy Of Melatonin In Cysteamine-induced Cataract In Rats
Hamdi ER*
The aim of the present study is to investigate anti-cataractogenic efficacy of melatonin that has antioxidant effect in cysteamine-induced experimental cataract. Twelve female Wistar rats were used in this study. Animals were divided into two groups, each consisting of 6 rats. Twelve eyes of six rats in group 1 received subconjunctival cysteamine and intraperitoneal melatonin. Twelve eyes of six rats in group 2 received subconjunctival cysteamine and intraperitoneal sterile saline. Mature cataract developed between 51 to 62 days (mean, 57.8 days) and between 47 to 57 days (mean, 53.8 days) in 8 eyes of 4 rats in group 1 and in group 2, respectively. No significant statistically difference was detected between two groups in terms of mean development of cataract (U=14.5, p=0.0633). We conclude that cysteamine is not a very suitable drug to induce experimental cataract formation, melatonin, however, is not able to prevent the development of cataract, especially in adult rats. Further studies are required to evaluate the efficacy of melatonin in delaying the formation of experimental cataract.Keywords: Cataract, Cysteamine, MelatoninTurkiye Klinikleri J Ophthalmol 1998, 7:100-103
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