ISSN: 1300-0365
Dil: Türkçe
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Copper, Zinc And Iron Levels In Diabeticand Senile Cataractous And Normal Human Lenses
Turhan Alçelİk*, Abdurrahim Koçyİğİt**, Özcan Erel**,Selçuk Bulut***, Şenel AvcI**, Necmeddin Aktepe**
* Dr.,Harran Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Dr.,Harran Üniversitesi Tıp Fakültesi Klinik Biyokimya ve Biyokimya AD, ŞanlIurfa*** Dr.,SB Ankara Hastanesi Göz Hastalıkları Kliniği, ANKARA
In 6 normal, 15 senile and 12 diabetic cataractous human lenses, copper (Cu), zinc (Zn) and iron (Fe) levels were detected in the present study to determine whether they had any effect on cataractogenesis. Lenticular Cu, Zn and Fe contents were measured by graphite furnace atomic absorption spectrophotometer. In the senile cataractous lenses, Fe accumulation were approximately 3 times, Cu 6 times and Zn 1.5 times more than the normal lenses. In the diabetic cataractous lenses, Fe accumulation were approximately 5, Cu 6 and Zn 1.5 times higher than the normal lenses. Increase in Fe content was significant (p<0.01) while Cu and Zn was not in diabetic cataractous lenses when compared to the senil cataractous lenses. There were positive correlations between Cu and Zn (r=0.602, p<0.05), Fe and Zn (r=0.633, p<0.05) in diabetic cataractous, and between Zn and Fe levels in senile cataractous lenses (r=0.917, p<0.001). Further studies would be needed to describe why the elements precipitates so much in cataractous lenses and by which mechanisms they cause cataractogenesis.Keywords: Senile cataract, diabetic cataract,
normal human lenses, copper, zinc, IronTurkiye Klinikleri J Ophthalmol 1998, 7:115-119
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