ISSN: 1300-0365
Dil: Türkçe
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Tear Lactate Dehydrogenase Activity In Pterygium Patients
Cengiz Onur*, İbrahim Ünsal**, Mehmet Orhan***, Murat İrkeç****
* Uz.Dr.,Hacettepe Üniversitesi Göz Hastalıkları AD,** Yrd.Doç.Dr.,Hacettepe Üniversitesi Biyokimya AD,*** Doç.Dr.,Hacettepe Üniversitesi Göz Hastalıkları AD,**** Prof.Dr.,Hacettepe Üniversitesi Göz Hastalıkları AD, Ankara
In pterygium, many functional alterations in tear are seen. In this study, tear lactate dehydrogenase (LDH) levels in pterygium cases and postoperative alterations in this enzyme activity is assessed. 37 patients who underwent pterygium excision accompanied with intraoperative topical mitomycin-C (n=19, group 1) and 5 FU (n=16, group 2) are included in this study. In both groups preoperative tear LDH activities (for group 1; LDH activity: 694.11±553.86 U/L and for group 2; LDH activity: 446.50±539.88 U/L) were not different from that of the control group. When the patients in mitomycin C group were followed in the early and late postoperative period, tear LDH levels were 661.42±787.33 U/L and 634.32±798.29 U/L in average respectively. In 5 FU group, tear LDH level was 406.01±539.24 U/L in early postoperative period, 546.44±700.33 U/L in late postoperative period. In both groups, preoperative tear LDH activity was not different from the control group. Also no statistical difference was observed between the preoperative and early/ late postoperative tear LDH levels. In conclusion, biochemical factors, especially biochemical components of tear LDH enzyme, has no role in the pathogenesis of pterygium. Also we conclude that pterygium and its surgery has no effect on the biochemical parameters of tear.Keywords: Pterygium, Tears, Lactate DehidrogenaseTurkiye Klinikleri J Ophthalmol 1998, 7:241-245
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