ISSN: 1300-0365
Dil: Türkçe
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The Effects Of Topical And Subconjunctival Aminocaproicacid In The Experimental Hyphema Model In Rabbits
Hamdi ER*, Abuzer Gündüz**
* Yrd.Doç.Dr.İnönü Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Araş.Gör.Dr.İnönü Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, Malatya
The objective of the present study is to investigate the effectiveness of topical and subjonjunctival aminocaproic acid in the treatment of hyphema occurred after trauma. Fifteen New Zealand male rabbits were used in this study. The animals were divided into 3 groups of 5 rabbits each according to treatment protocol. Topical 3x1 aminocaproic acid and 0.5 cc subconjunctival aminocaproic acid (75 mg/cc) were used in group 1 and group 2 eyes respectively. Remained 5 eyes served as the control group (group 3). The animals were monitored by slit-lamp through 5 days at average 6 and 12 hours intervals. The mean resolving time of hyphema was 48, 36 and 120 hours in group 1, group 2 and control group, respectively. Although, there was statistically significant difference (U=3.0, p<0.05) between treatment groups only at 12 hours in terms of resolving time of hyphema, no statistically significant differences were detected at another times (p>0.05). Statistically significant difference was however, detected between treatment and control groups at all times (p<0.05). In conclusion, we reached that topical and subconjunctival aminocaproic acid should be included among the other treatment methods of traumatic hyphema that will possibly reduce the incidence of secondary hemorrhage.Keywords: Aminocaproic acid, Eye trauma,
Seconder hemorrhage, HyphemaTurkiye Klinikleri J Ophthalmol 1998, 7:258-261
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