ISSN: 1300-0365
Dil: Türkçe
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The Effect Of 1% Apraclonidine On Intraocular Pressurewhen Added To Beta Blocker And Cholinergic Treatment
Volkan DayanIr*, Seyhan B ÖZKAN**, Erkin KIR***
* Yrd.Doç.Dr, Adnan Menderes Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Doç.Dr., Adnan Menderes Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, AYDIN*** Uz.Dr., İzmir 600 Yataklı Hava Hastanesi, İZMİR
This study was conducted in order to investigate the short term effect of 1% Apraclonidine on intraocular pressure (IOP) when added to beta-blocker or concurrent cholinergic treatment.
Retrospective evaluation was done on 23 patients with the diagnoses of primary open angle glaucoma in 18, pseudoexfoliative glaucoma in 3, aphakic glaucoma in 1, and angle closure glaucoma in 1 who were on beta-blocker or concurrent cholinergic treatment. Intraocular pressures were measured by Goldmann applanation tonometer. Apraclonidine was used twice a day and measurements were repeated between 7-10 days.
Pre-apraclonidine IOP ranged between 16.5 to 36.0 mm Hg (mean ± standard deviation, 24.4 ± 1.0). Post-apraclonidine IOP were between 15.0 to 29.0 (19.9 ± 0.7), with a mean drop of 4.1 ± 0.5 mmHg. The drop was found to be significant when compared with paired samples t-test (p = 0.000). Besides two patients with pseudoexfoliative glaucoma, one of which was treated with argon laser trabeculoplasty and the other with trabeculectomy, all had IOP at safe levels with medical treatment.
Due to inadequate numbers, it was not possible to do any statistical workup in pseudoexfoliative patients. 1% Apraclonidine twice a day was found to lower IOP in short term when added to non selective beta-blocker or concurrent cholinergic treatment. We believe that the effect of the drug on different types of glaucoma should be investigated on larger groups.Keywords: Glaucoma, Apraclonidine, Beta-BlockerTurkiye Klinikleri J Ophthalmol 1999, 8:184-187
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