ISSN: 1300-0365
Dil: Türkçe
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Betaxolol And Pilocarpine In Normal Tension Glaucoma Patients
M.Erol TURAÇLI*, Yavuz BARDAK**, Rabia GÜRSES ÖZDEN**, Mehmet Ali GÜRSES***
* Prof.Dr., Ankara Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Uzm.Dr., Serbest*** Araş.Gör.Dr., Ankara Üniversitesi Tıp Fakültesi Radyo-Diagnostik AD, ANKARA
To compare the effects of betaxolol and pilocarpine in normal tension glaucoma patients.
40 eyes of the 20 patients were included in this study. Patients were divided into two equal groups; group I used only betaxolol and group II used only pilocarpine. After 1 year, pretreatment and posttreatment results of visual acuity, vertical cup/disc, intraocular pressure (IOP), computerized perimetry, color Doppler ultrasonography results were compared.
There were no difference between two groups before and after 1 year treatment in visual acuity, vertical c/d ratio. The IOP decrease in betaxolol group was -1.14±2.03 mmHg; and in pilocarpine group was -2.58±2.61 mmHg (in turn: p<0.01, p<0.05). After 1 year treatment; in betaxolol group ophthalmic artery (OA) resistive index (RI) decreased from 0.68±0.06 to 0.65±0.07; in pilocarpine group OA RI decreased from 0.75±0.07 to 0.70±0.09 (for betaxolol and pilocarpine groups p<0.01). In both groups there were no significant difference between pretreatment and posttreatment reliability indexes of computerized perimetry. In betaxolol group there was a significant increase in (-) mean deviation (-MD) and corrected pattern standard deviation (CPSD) values after 1 year treatment (pre-treatment and post-treatment; -MD: 6.76±4.63 dB and 5.02±2.83 dB; CPSD: 4.90±3.01 db and 3.57±2.17 dB) (-MD p<0.05, CPSD p<0.01). In pilocarpine group short gluctuation decreased from 2.81±1.06 dB to 2.36±0.79 dB after 1 year treatment (p<0.05).
In normal tension glaucoma patients betaxolol and pilocarpine caused decrease in OA RI and increase in some visual field parameters.Keywords: Normal tension glaucoma, Betaxolol, Pilocarpine,
Visual acuity, Vertical cup/disc, Computerized
perimetry, Color Doppler ultrasonographyTurkiye Klinikleri J Ophthalmol 1999, 8:163-170
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