ISSN: 1300-0365
Dil: Türkçe
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Penetration Of Subconjunctival Ceftazidim To Aquous Humor
M. Erol TuraçlI*, Suat Hayri Uğurbaş**, Murat Özsan***, Buket Cİcİoğlu****
* Prof.Dr., Ankara Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Araş.Gör.Dr., Ankara Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,*** Doç.Dr., Ankara Üniversitesi Tıp Fakültesi Mikrobiyoloji AD,**** Araş.Gör.Dr., Ankara Üniversitesi Tıp Fakültesi Mikrobiyoloji AD, ANKARA
Aim: Preliminary study to determine the penetration of subconjunctival ceftazidim to aquous humor for its prophylactic use in ocular trauma and intraocular surgery.
Methods: 125 mg Subconjunctival ceftazidim was injected to 12 patients who were undergoing a planned extracapsular cataract extraction. Aquous samples obtained in 15 minutes to 6.5 hours after the operation were measured with agar-gel diffusion technic.
Results: Subconjunctival 125 mg ceftazidim has reached the effective level in aquous after 15 minutes to 3.5 hours following injection.
Conclusion: Subconjunctival 125 mg ceftazidim that reaches the effective level in a short time and maintains this level during a period long enough for intraocular surgery, may have a place for use in trauma cases and intraocular surgery.Keywords: Surgical profilaxis, Ceftazidim,
Subcojunctival injection,
Drug level in aquous humor.Turkiye Klinikleri J Ophthalmol 2000, 9:24-26
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