ISSN: 1300-0365
Dil: Türkçe
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The Efficacy Of Apraclonidine Use In The Preventionof Intraocular Pressure Spikes Which Occur Duringpupillary Dilatation In Glaucoma Cases
İbrahim Koçer*, Destan Kulaçoğlu*, Gülay Güllülü**, Osman Dursun***
* Yrd.Doç.Dr., Atatürk Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Prof.Dr., Atatürk Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,*** Araş.Gör.Dr., Atatürk Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, ERZURUM
Purpose: It was aimed to investigate the increases in intraocular pressure(IOP) during pupillary dilatation obtained by using tropicamide (%1) plus phenylephrine HCl (%10) installation in primary open angle glaucoma (POAG) cases and to evaluate the effect of apraclonidine prophylaxis on IOP spikes.
Material and Method: Thirty-one eyes of 19 patients with POAG taking beta blockers+pilocarpine nitrate were included in this study.After the measurements of IOP's, apraclonidine or artificial tears (placebo) drops were instilled. Thirty minutes later, tropicamide (%1) plus phenylephrine HCl (%10) eye drops were applied. IOP's were measured an hour and two hours after drug administration. The data obtained from apraclonidine and placebo groups were statistically evaluated.
Results: The baseline IOPs were 16.19±3.21 and 15.87±3.37 mmHg in the placebo and apraclonidine groups. The difference was not significant (p>0.05). Additionally, apraclonidine group had higher IOP values both at the first and second hours than the placebo group had. (20.84± 4.54 vs 17.58±4.09 at the first hour, 22.74±4.86 vs 18.03±4.09 at the second hour) The differences were statistically meaningful (p<0.01 and p<0.001, respectively).
Conclusion: It was concluded that the prophylactic use of topical apraclonidine may prevent IOP spikes which occur after pupillary dilatation necessary for the diagnostic procedure and follow up of patients with POAG.Keywords: Pupillary dilatation, apraclonidine,
Intraocular pressure spikeTurkiye Klinikleri J Ophthalmol 2000, 9:112-115
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