ISSN: 1300-0365
Dil: Türkçe
|
|
|
Toxic Effects Of Extraocularly Applied Mitomycin C In A Rabbit Model
Sema Oruç*, Diclehan Orhan**, Mehmet Orhan***, Murat İrkeç****
* Yrd.Doç.Dr., Adnan Menderes Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, AYDIN** Uz.Dr., Ankara Üniversitesi Tıp Fakültesi Patoloji AD,*** Doç.Dr., Hacettepe Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,**** Prof.Dr., Hacettepe Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, ANKARA
We performed a prospective study to determine the intraocular toxic effects of mitomycin-C (MMC), which is widely used to increase the success rate of glaucoma filtering surgery. Clinically, severe prolonged postoperative hypotony has been a frequent complication of glaucomatous filtration surgery in which MMC was used. We placed MMC, in concentrations of 0.2 mg/ml, and 0.4 mg/ml on the intact sclera of rabbits and enucleated the eyes after 15 days. Examination of all of the eyes by light microscopy revealed normal intraocular structures, including the cornea, lens, ciliary body, and retina. In this experimental model, MMC appeared non-toxic at these doses of administration.Keywords: Glaucoma filtering surgery, mitomycin-C,
histopathology, rabbit modelTurkiye Klinikleri J Ophthalmol 2000, 9:83-86
|
|
|
|
|
