ISSN: 1300-0365
Dil: Türkçe
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Effect Of Taurolidine On The Eyelid And Conjunctival Flora
Halit Oğuz*, Elif Oğuz**, Sezin Karadede***
* Yrd.Doç.Dr., Harran Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Ecz., Harran Üniversitesi Tıp Fakültesi Araştırma ve Uygulama Hastanesi,*** Prof.Dr., Harran Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, ŞanlIurfa
Purpose: We evaluated the effectiveness of the topical taurolidine in eradicating or reducing microorganisms on the normal flora of eye in a randomized controlled study.
Materials and Methods: Ninety eyes of 72 patients awaiting cataract surgery were randomly divided into three groups consisting of 30 eyes each. The first group received 0.05% taurolidine, the second received 0.3 % gentamicin and the third received vehicle eyedrops to the preoperative eye four times daily for two days. Cultures were obtained from the eyelids and conjunctivas of all subjects prior to the instillation and again at the end of 48 hours. Microbiological identification and colony counts were performed by standard laboratory methods, and the results were compared.
Results: Taurolidine and gentamicin produced a significant decrease from the basal bacteriological state: the number of colonies (p=0.003 for taurolidine, p=0.007 for gentamicin) and species (p=0.0002 for taurolidine, p=0.0012 for gentamicin) were reduced by both agents. Staphylococcus epidermidis was the commonest microorganism isolated before the instillation, and the number of its colonies was significantly reduced in taurolidine (p<0.0003) and gentamicin-treated (p=0.0011) subjects.
Conclusion: Taurolidine solution with its unique properties is an effective antimicrobial agent on the flora of the eye. It appears to be a promising new antimicrobial drug for ocular infections.Keywords: Antimicrobial, Conjunctival flora, Eyelid flora,
Taurolidine, TaurolinTurkiye Klinikleri J Ophthalmol 2000, 9:184-188
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