ISSN: 1300-0365
Dil: Türkçe
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Apoptosis: Its Place In Eye Diseases
Özlem Evren Abbasoğlu*, Banu M. Hoşal*
* Op.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 2. Göz Kliniği, ANKARA
Apoptosis is a form of programmed cell death which is evident under physiological and pathological conditions. During apoptosis DNA is uniformly fragmented and condensed, stability of cellular and organel membranes are preserved and the cell is phagocytized by neighbouring cells. Apoptosis can be detected by using electron microscopy, immune histochemical labeling techniques and gel electrophoresis. It is evident under physiological conditions like embrogenesis and tissue hemostasis as well as under pathological conditions like ischemia, presence of toxic factors and neoplastic changes. Apoptosis is regulated by oncogenes like p53, Bcl-2, Rb and c-fos. In ophthalmology, it plays role in pathogenesis of diseases like retinoblastoma, retinal degenerations, keratoconus and glaucoma. The mechanism of apoptosis and its role in eye diseases will be discussed in this review.Keywords: Apoptosis, Retinoblastoma, Retinitis pigmentosa, Retinal ischemia, Keratoconus, GlaucomaTurkiye Klinikleri J Ophthalmol 2001, 10:115-120
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