ISSN: 1300-0365
Dil: Türkçe
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Antibody Titers Of Coxsackie Viruses Of Group B In BehÇet's Disease With Or Without Ocular Involvement
Alper TEKELİ*, Oya TEKELİ**, Murat ÖZSAN***, Taner KARAOĞLU****, Özden ÖZDEMİR*****
* Uz.Dr., Ankara Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Kliniği,** Uz.Dr., Ankara Üniversitesi Tıp Fakültesi Göz Hastalıkları Kliniği,*** Doç.Dr., Ankara Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Kliniği,
Purpose: Behçet's disease (BD) is a multisystem disorder. Various investigators have attempted to identify an exogenous cause to this disease, particularly a viral one. In the present study we investigated antibody titers of coxsackie viruses group B (CVB) in BD.
Method: The study groups included 20 (31.7%) patients who had active ocular involvement (group 1), 13 (20.6%) patients who had clinical evidence of previous ocular disease (group2), 30 (47.6%) patients without ocular involvement (group 3), and 30 healthy control subjects. Sera of the patients and control subjects were analysed by using microplate neutralisation test.
Results: There were no statistically significant differences between group 1, 2 and 3 for distrubition of CVB1, B2, B3, B4, B5, B6 antibodies titers and no differences between group 1, 2, 3 and control group ( Kruskal-wallis ANOVA).
Conclusion: We conclude that CVB may not be responsible for pathogenesis of BD with or without ocular involvement.Keywords: Behçet's disease, coxsackie virus group B, uveitisTurkiye Klinikleri J Ophthalmol 2001, 10:83-87
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