ISSN: 1300-0365
Dil: Türkçe
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Second Step Drug Choice In Medical Treatment Of Glaucoma
Selim DOĞANAY*, Hamdi ER**, Erhan ÜZMEZ***, Cem EVEREKLİOĞLU****, Mehmet BORAZAN*****
* Yrd.Doç.Dr., İnönü Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Doç.Dr., İnönü Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, MALATYA*** Serbest Hekim**** Yrd.Doç.Dr., Gaziantep Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, GAZİANTEP
Purpose: To compare the additive effects of latanoprost 0.005% (Xalatan), dorzolamide 2% (Trusopt) or apraclonidine 0.5% (Iopidine) in patients with primary open-angle or pseudoexfoliative glaucoma who have uncontrolled intraocular pressure (IOP) with betaxolol 0.25% (Betoptic-S) alone.
Methods: The patients who were receiving betaxolol twice a day were divided into 3 treatment groups: Group I (n=11) was treated with betaxolol and latanoprost, Group II (n=15) was treated with betaxolol and dorzolamide, Group III (n=11) was treated with betaxolol and apraclonidine. Intraocular pressures were measured 1, 2, 3 and 4 weeks after treatment.
Results: Before the treatment, mean IOP in groups I, II, III were 21.63±1.91, 21.33±1.63, 21.90±2.16 mm-Hg, respectively. After 4 weeks, mean IOP values were 14.54±1.21 mm-Hg in Group I, 15.20±1.14 mm-Hg in Group II, 17.54±1.36 mm-Hg in Group III mm-Hg. Mean reduction in IOP at 4 weeks compared with baseline was 7.09 mm-hg (32.78 %) in group I, 6.13 mm-Hg (28.74 %) in group II, 4.36 mm-Hg (19.91 %) in group III. There was no statistically significant difference between group I, II at 2, 3, and 4 weeks (p=0.1 and 0.3), the difference was statistically significant between groups I-III and groups II-III at 2, 3 and 4 weeks (p<0.05).
Conclusion: These results support that especially, latanoprost or dorzolamide should be choosen as second step drugs in patients whose IOP was in adequately dropped with betaxolol alone.Keywords: Latanoprost, dorzolamide, apraclonidine, glaucoma, Intraocular pressureTurkiye Klinikleri J Ophthalmol 2001, 10:78-82
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