ISSN: 1300-0365
Dil: Türkçe
|
|
|
Effects Of Betaxolol And Flunarizine On Visual Fields And Intraocular Pressure In Migraine
Alper Yarangümeli*, Selçuk Çomoğlu**, Özlem Gürbüz Köz*, Atilla Halil Elhan***, Gülcan Kural****
* Uz.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 1. Göz Kliniği,** Uz.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi Nöroloji Kliniği,*** Arş.Gör., Ankara Üniversitesi Tıp Fakültesi, Biyoistatistik AD,**** Uz.Dr., Ankara Numune Eğitim ve Araştırma Hastanesi 1. Göz Kliniği, Şefi, ANKARA
Purpose: To investigate the effects of topical betaxolol and systemic calcium channel blocker flunarizine on visual fields (VF) and intraocular pressure (IOP) in patients with migraine.
Materials and method: Patients with migraine who were referred to our clinic between June 1999 and June 2000 underwent detailed ophthalmologic examination. IOP measurements and VF tests were performed and patents were divided into four groups. The first group (Group 0) was followed with no medications, topical betaxolol (bid) was precribed to the second group (Group B), oral flunarizine (10 mg daily) was prescribed to the third group (Group F), and the last group (Group BF) was assigned for combined betaxolol and flunarizine treatment. After a mean follow-up time of 4.2±1.2 months (3 to 6 months), ophthalmologic examinations, IOP measurements and VF tests were repeated, and the results of 51 cases (51 eyes) who completed the study were evaluated.
Results: Group B and Group BF were found to be statistically different from the other groups in terms of IOP reduction and VF improvement according to mean deviation and corrected pattern standard deviation indices in the second examinations. On the other hand, Group F and Group BF differed from the other two groups considering the improvement in migrainous complaints.
Conclusion: VF findings which are probably influenced by perfusion problems due to vasospastic mechanisms in migraineurs, improved following topical betaxolol treatment. However, systemic use of flunarizine -a calcium channel blocker- did not seem to be effective on visual fields although it had beneficial effects on migraine.Keywords: Migraine, Visual field, Betaxolol, FlunarizineTurkiye Klinikleri J Ophthalmol 2001, 10:190-198
|
|
|
|
|
