ISSN: 1300-0365
Dil: Türkçe
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Amniotic Membrane Transplantation Inocular Surface Reconstruction
Ö. Ömür Uçakhan*, Gültekin Köklü**, Esin FIrat***
* Dr., Ankara Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Dr., Sosyal Sigortalar Kurumu, Ankara Göz Eğitim Hastanesi,*** Doç.Dr., Sosyal Sigortalar Kurumu, Ankara Göz Eğitim Hastanesi, ANKARA
Purpose: To evaluate the safety and efficacy of non-preserved amniotic membrane transplantation (AMT) with or without limbal autograft transplantation (LAT) in ocular surface reconstruction.
Materials and Methods: Amniotic membrane transplantation or AMT+LAT was performed on 11 eyes of 9 consecutive patients referred to SSK Ankara Eye Hospital; 5 eyes with persistent epithelial defect (PED) due to acute chemical burn, 4 eyes with limbal stem cell insufficiency secondary to chemical burn, 1 eye with PED due to drug toxicity, and 1 eye with PED and stromal lysis post-pterygium surgery. Non-preserved amniotic mebrane was used in all procedures.
Results: Four (44.5%) patients were females and 5 (55.5%) were males, average age at the time of surgery was 41.2±18.4 years (range; 20 to 73 years). Mean follow-up after last surgery was 8.9±3.5 months (range; 3 to 14 months). The average epithelial healing time was 23.9±15.8 days (range; 3 to 45 days). At the end of the follow-up period visual acuity improved in all eyes. Inflammation subsided and the subjective complaints decreased remarkably.
Conclusion: AMT, promoted epithelial healing, reduced surface inflammation, increased patient comfort, decreased extent and severity of vascularization and avoided episodes of recurrent erosion or excessive fıbrosis when used in patients with PED. When used in limbal stem cell deficiency - AMT alone or in combination with LAT - helped ocular surface reconstruction. Infection, inflammation or toxic/allergic reactions were not encountered in any patient due to the use of non-preserved amniotic membrane. Further studies are reor non-preserved AMT in ocular surface reconstruction.Keywords: Amniotic membrane transplantation, Limbal autograft transplantation, Ocular surface reconstruction, Chemical eye injury, Chemical burn, Persistant epithelial defect, Drug toxicityTurkiye Klinikleri J Ophthalmol 2001, 10:199-205
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