ISSN: 1300-0365
Dil: Türkçe
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Limbal Stem Cells And Their Clinical Significance
Özgür ŞANLI*, Murat DOĞRU**, Haluk ERTÜRK***
* Arş.Gör.Dr., Uludağ Üniversitesi Tıp Fakültesi, Göz Hastalıkları AD,** Yrd.Doç.Dr., Uludağ Üniversitesi Tıp Fakültesi, Göz Hastalıkları AD,*** Prof.Dr., Uludağ Üniversitesi Tıp Fakültesi, Göz Hastalıkları AD, BURSA
This article focuses on the clinical and experimental evidence about the existence of limbal stem cells which are thought to play an important role in corneal regeneration. Limbal stem cell deficiency results in progressive invasion of the cornea by the conjunctival epithelium, superficial corneal neovascularization, epithelial basement membrane damage and chronic inflammatory cell infiltration in the cornea. The initial reported methods of ocular surface reconstruction included conjunctival transplantation and keratoepithelioplasty. Limbal transplantation is probably the best current option for ocular surface reconstruction in patients with total corneal stem cell deficiency. It has been reported that auto or allograft transplantation and simultaneous ammiotic membrane transplantation provides favourable results in unilateral limbal stem cell deficiency. Recently, it has been advocated that solitary amniotic membrane transplantation is an effective treatment modality in partial limbal stem cell deficiency.Keywords: Limbal stem cell, Ocular surface, Amniotic membrane transplantationTurkiye Klinikleri J Ophthalmol 2002, 11:227-232
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