ISSN: 1300-0365
Dil: Türkçe
|
|
|
The Effect Of Topical Latanoprost On Retrobulbar Bloodflow In Patients With Primary Open Angle Glaucoma Andocular Hypertension
Ümit Übeyt İNAN*, Sıtkı Samet ERMİŞ*, Aylin YÜCEL**, Faruk ÖZTÜRK***
* Yrd.Doç.Dr., Kocatepe Ünivesitesi Tıp Fakültesi Göz Hastalıkları AD,** Yrd.Doç.Dr., Kocatepe Ünivesitesi Tıp Fakültesi Radyoloji AD,*** Doç.Dr., Kocatepe Ünivesitesi Tıp Fakültesi Göz Hastalıkları AD, AFYON
Purpose: To investigate the effects of topical latanoprost 0.005% on retrobulbar vessel blood velocity in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH).Material and Methods: Twenty three patients with POAG or OH were enrolled for this study. All patients were treated topically with latanoprost 0.005% (Xalatan). Follow-up was three months. Each patients had a baseline color Doppler imaging ultrasound of the central retinal artery, temporal short posterior ciliary arteries, and ophtalmic artery and second color doppler ultrasound examination three months later. Intraocular pressure in each patient was also recorded with Goldman applanation tonometer before the treatment and at the end of three months follow-up.Results: In three patients, latanoprost was discontinued one week after treatment because of ocular side effects. Twenty patients completed the study. Topical latanoprost significantly reduced intraocular pressure (p<0.05). The only significant change observed in the retrobulbar blood velocity with latanoprost treatment was an increase of peak systolic velocity in the ophthalmic artery (p<0.05). No change in the other blood velocity measurements was observed with latanoprost.Conclusion: Topical latanoprost significantly reduced the intraocular pressure in ocular hypertensive and glaucoma patients without causing significant hemodynamic changes in the retrobulber vessels.Keywords: Latanoprost, IOP, Retrobulbar Blood FlowTurkiye Klinikleri J Ophthalmol 2002, 11:130-133
|
|
|
|
|
