ISSN: 1300-0365
Dil: Türkçe
|
|
|
Long-term Outcomes Of Low-dose 5-fluorouracil Versus Mitomycin-c In High-risk Glaucoma Surgery
Cengiz AKARSU*, Merih ÖNOL**, Berati HASANREİSOĞLU**
* Yrd.Doç.Dr., Kırıkkale Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, KIRIKKALE**Prof.Dr., Gazi Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, ANKARA
Objective: To compare low dose postoperative 5-fluorouracil (5-FU) with intraoperative mitomycin-C (MMC) for efficacy and safety as an adjunct to trabeculectomy in high-risk glaucoma patients.
Institution: Department of Ophthalmology, School of Medicine, Gazi University, Ankara.
Materials and Methods: In a retrospective, nonrandomized comparative trial, 36 eyes of 36 patients at high-risk for failure of trabeculectomy underwent glaucoma filtering surgery with either postoperative subconjunctival low-dose (total 15-25 mg) 5-FU injections (19 eyes) or intraoperative application of MMC (0.4 mg/ml, 3 min, 17 eyes). Success was defined as intraocular pressure (IOP) of 21 mmHg with or without medications.
Results: Overall success at 1 year was 73.6% in the 5-FU group and 82.3% in the MMC group. The cumulative 5 years success was 52.6% in the 5-FU group and 63.5% in the MMC group. The difference between the groups was not statistically significant (p=0.5). The postoperative mean IOP at 5 years was lower in eyes receiving MMC than that of eyes receiving 5-FU (p=0.001). There was no significant difference in number of medications (p=0.80), appearance of blebs (p=0.20), final visual acuity (p=1.00), and complications (p>0.05).
Conclusions: Although both 5-FU and MMC appear to have good IOP control in high-risk patients, MMC results in a greater decrease in IOP than 5-FU.Keywords: Trabeculectomy, High-risk glaucoma, 5-Fluorouracil, Mitomycin-CTürkiye Klinikleri Oftalmoloji 2003, 12:192-199
|
|
|
|
|
