ISSN: 1300-0365
Dil: Türkçe
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Pterygium And Mast Cell
S. Samet ERMİŞ*, Fatma AKTEPE**, Ümit Ü. İNAN*, Faruk ÖZTÜRK***, Hüsniye DİLEK**
* Yrd.Doç.Dr., Afyon Kocatepe Üniversitesi Tıp Fakültesi Göz Hastalıkları AD,** Yrd.Doç.Dr., Afyon Kocatepe Üniversitesi Tıp Fakültesi Patoloji AD,*** Doç.Dr., Afyon Kocatepe Üniversitesi Tıp Fakültesi Göz Hastalıkları AD, AFYON
Objective: Mast cells are known for their role in inflammatory and immunologic reactions. In order to investigate the role of mast cells in the pathogenesis of pterygium we compared the number of mast cells in excised pterygium and normal conjunctival tissue obtained from healthy eyes of patients with unilateral pterygium. Materials and Methods: Twenty-eight patients with unilateral pterygium in whom primary excision were performed were included in the study. Specimens obtained from excised pterygium and nasal conjunctiva of healthy eyes were examined histopathologically. Mast cells were counted at a magnification of 400 by using light microscope. The horizontal length of pterygium was measured with milimetric scale of biomicroscope. Results: Mast cells were identified in the stroma as perivascular mononuclear cells containing metachromatic granules. The mean cell count was 17.4±8.7 in pterygium specimens and 8.4±3.0 in normal conjunctiva. There was no significant correlation between mast cell count and pterygium length. (Pearson's correlation coefficient r=0.086, p=0.66).Conclusion: Mast cells were found to be increased in pterygia. Although the role of mast cells in the pathogenesis of pterygium is not exactly known, it may contribute to the pathogenesis due to its close relation with inflammatory and immunologic conditions and containing vasoactive mediators.Keywords: Pterygium, Mast cells, Conjunctiva, EtiologyTurkiye Klinikleri J Ophthalmol 2003, 12:92-95
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