ISSN: 1300-0365
Dil: Türkçe
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ORIGINAL RESEARCH ARTICLES |
The Effects Of Prostaglandin E2 Amount On Ocular Inflammation In Rabbit Eyes After Phacoemulsification
Dr. Sevin SÖKER ÇAKMAK,a Dr. Kaan ÜNLÜ,a Dr. Hüseyin BÜYÜKBAYRAMbDr. Şeyhmuz ARI,a Dr. Sevda İpek SÖKERc
aGöz Hastalıkları AD, Dicle Üniversitesi Tıp Fakültesi,bPatoloji AD, Dicle Üniversitesi Tıp Fakültesi,cHistoloji ve Embriyoloji AD, Dicle Üniversitesi Tıp Fakültesi, DİYARBAKIR
Objective: To evaluate the relation between Prostaglandin E2 (PGE2) secretion of lens epithelial cells and inflammation posterior capsule opacification occured after phacoemulsification and intraocular lens (IOL) implantation in rabbit eyes.
Material and Methods: 12 eyes of 6 rabbits were studied. One eye of each rabbit was operated with phacoemulsification and IOL implantation, the other eye was operated with only phacoemulsification. After operation at 1, 3, 7, 30, 60 and 90 days 10 цl of aque-ous humor was taken, and leukocyte counts and PGE2 levels were detected. After enucleation at 90th day, posterior capsule weights were measured. Histopathologic changes that were observed in lens epithelial cells were also analyzed at light microscopy.
Results: The relation among PGE2 levels in aqueous humor samples, which were taken from pseudoaphakic and aphakic eyes at 1, 3, 7, 30, 60 and 90 days was not found significant (p>0.05). Leukocytes were observed in aqueous humor samples that were taken at 1. and 3. days. While mean leukocyte level in pseudoaphakic eyes was 12/цl, it was 4/цl in aphakic eyes. There were significant differences between the groups regarding the disribution of white blood cells subsets (P<0.05). Mean posterior capsule weight in IOL implanted eyes was 105.4 mg, but it was 92.1 mg in eyes without IOL implantation (P>0.05). At light microscopy, proliferation in lens epithelial cells and enflamation was much more in pseudoaphakic eyes than aphakic ones (Figure 2, 3).
Conclusion: Inflammation in pseudoaphakic eyes was more than in aphakic eyes. PGE2 levels in aqueous humor may have an important role in the pathogenesis of postoperative inflammation in cataract surgery.Keywords: Ocular inflammation, PGE2, Lens epithelial cells, blood- aqueous barrierTurkiye Klinikleri J Ophthalmol 2004, 13:216-220
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